Dr Saggar began his career at St Bartholomew's Hospital, London and then went on to work in several London teaching hospitals. He has a comprehensive record of experience in respiratory medicine, diabetes/endocrinology, cardiology, intensive care, nephrology (kidney disorders) and neurology.

In 1988 he became a full time academic, and undertook research  at two centres of international repute: The department of renal medicine, Karolinska Institute in Sweden and later in the Blood pressure unit at St Georges Medical School, London.

Dr Saggar completed his training in Clinical Genetics through St Georges NHS Trust and Great Ormond Street NHS Trust. He was appointed a consultant in 2000.